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| Registros recuperados: 18.055 | |
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| 木下, 幹朗; 柚木, 恵太; 得字, 圭彦; 川原, 美香; 大庭, 潔; 弘中, 和憲; 大西, 正男; Kinoshita, Mikio; Yunoki, Keita; Tokuji, Yoshihiko; Kawahara, Mika; Ohba, Kiyoshi; Hironaka, Kazunori; Ohnishi, Masao. |
| ナガイモのガンに対する機能性を探索する目的で， 1,2- ジメチルヒドラジン投与マウスにおける大腸腺腫(ACF) 発症に与える食餌性ナガイモ粉末の効果を検証した.ナガ イモ粉末をAIN-93G標準飼料のコーンスターチ部分に 100%または50%置き換えて投与したところ，大腸腺腫の 発症が有意に抑制されたまた，加熱および非加熱の生ナ ガイモ粉末ともに同様の効果が認められた. DNAマイク ロアレイを用いて大腸での遺伝子の異同を調べたところ， ナガイモ投与群ではアポ卜ーシスを誘導する遺伝子群の増加が認められた.To clarify the physiological effects of dietary Chinese yam (Nagaimo) on colon cancer in vivo， the effects of dietary Nagaimo on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) formation in the large intestine of mice were investigated. After 8 weeks of feeding raw or boiled Nagaimo and DMH administration，DMH-induced ACF formation was found to be significantly suppressed in the large intestines of all mice. DNA microarray analysis showed that levels of apoptosis-inducing gene expression in... |
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Palavras-chave: ナガイモ 大腸腺腫 大腸ガン 1，2-ジメチルヒドラジン DNAマイクロアレイ Chinese yam (Nagaimo) aberrant crypt foci colon cancer 1; 2-dimethylhydrazine DNA microarray. |
| Ano: 2008 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2706 |
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| Mauting Lin; Carl D. Morrison; Susie Jones; Nehad Mohamed; Jason Bacher; Christoph Plass. |
| Gene amplification, a common mechanism for oncogene activation in cancers, has been used in the discovery of novel oncogenes. DNA amplification is frequently observed in head and neck squamous cell carcinomas (HNSCCs) where numerous amplification events and potential oncogenes have already been reported. Recently, we applied restriction landmark genome scanning (RLGS) to study gene amplifications in HNSCC and located novel amplified and uncharacterized regions in primary tumor samples. DNA amplification on 8q22.3, the location of 14-3-3[zeta] (YWHAZ, KCIP-1) is found in 30-40% HNSCC cases. Data obtained from fluorescent in-situ hybridization (FISH) and immunohistochemistry on HNSCC tissue microarrays confirmed frequent low-level 14-3-3[zeta] copy number... |
| Tipo: Manuscript |
Palavras-chave: Cancer. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1953/version/1 |
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| Mihail Bota; Larry Swanson. |
| The goal of this workshop was to agree on a general strategy for developing a systematic, useful, and scientifically appropriate framework for neuroanatomical nomenclature. The workshop focused on general principles that will serve as a basis for future decisions on implementation strategies. The report discusses the problems arising from the use of different parcellation schemes and use of different terminologies and highlights the need of a universal vocabulary for describing the structural organization of the nervous system. Workshop participants encourage the creation of an International Coordinating Committee for Neuroanatomical Nomenclature and propose short- and long-term goals for such a committee. |
| Tipo: Manuscript |
Palavras-chave: Neuroscience; Bioinformatics; Data Standards. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1780/version/1 |
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| Registros recuperados: 18.055 | |
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